Hydrazine → 4-phenyl-1H-pyrazolo[5,4-c]pyridazin-3-amine
反応式
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9].[NH2:16][NH2:17]>C(O)C>[C:10]1([C:6]2[CH:5]=[N:17][N:16]=[C:2]3[NH:3][N:4]=[C:8]([NH2:9])[C:7]=23)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1参加物
4
実験手順
3-Chloro-5-phenyl-pyridazine-4-carbonitrile obtained from Step B was suspended in 1 ml ethanol with 23 μL hydrazine and the mixture was refluxed for several hours. The solvent was then evaporated and the title product was purified by silica gel chromatography (1:9 methanol/dichloromethane): MS (ES+) 212 (M+H); HPLC 1.121 minutes.
後処理
- temperaturethe mixture was refluxed for several hours
- customThe solvent was then evaporated
- customthe title product was purified by silica gel chromatography (1:9 methanol/dichloromethane)
- customHPLC 1.121 minutes
出典と根拠
- ORDレコード
- ord-a60c7f5a9dae42fe9e9782d65a3b2ebd
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318467B2
反応ノート
読み込み中…