N-methyl-2-pyrrolidone → 3-Chloro-2-isopropylsulfonyl-1-nitrobenzene
反応式
[CH:1]([S:4]([O-:6])=[O:5])([CH3:3])[CH3:2].[Na+].CN1CCCC1=O.Cl[C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24]>O>[Cl:22][C:21]1[C:16]([S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[C:17]([N+:23]([O-:25])=[O:24])[CH:18]=[CH:19][CH:20]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a mixture of sodium isopropylsulfinate (3.3 g) and N-methyl-2-pyrrolidinone (20 mL), 2,3-dichloronitrobenzene (4 g) was added and stirred overnight at 70° C. The reaction mixture was diluted with water, and the precipitated solid was collected by filtration and washed with diethyl ether to give 3-chloro-2-isopropylsulfonyl-1-nitrobenzene (3.0 g) as a white solid.
後処理
- additionwas added
- filtrationthe precipitated solid was collected by filtration
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-13d5fda60e4d4100b3cdfdeaab8f0bcc
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318702B2
反応ノート
読み込み中…