ClC(Cl)C.[Br:5][C:6]1[CH:15]=[N:14][C:13]2[NH:12][C:11](=O)[C:10]([CH3:18])([CH3:17])[O:9][C:8]=2[CH:7]=1.P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:25][NH2:26]>C(Cl)Cl>[Br:5][C:6]1[CH:15]=[N:14][C:13]2[NH:12]/[C:11](=[N:26]/[CH3:25])/[C:10]([CH3:18])([CH3:17])[O:9][C:8]=2[CH:7]=1A dichloroethane (5 mL) solution of 7-bromo-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (520 mg, 2 mmol) and phosphorus pentachloride (840 mg, 4 mmol) was irradiated in a microwave oven for 10 min at 160° C. The solution was cooled to −78° C. and methylamine (2M in THF) was added it slowly until it became permanently basic. The mixture was diluted with CH2Cl2, washed with dilute solution of NaOH, dried and evaporated. Crystallization from CH2Cl2/hexane afforded 480 mg (89%) of the title compound. 1H NMR (300 MHz, CDCl3, 8) 8.07 (d, J=2.1 Hz, 1H), 7.21 (d, J=2.1 Hz, 1H), 4.9 (s, br, 1H), 3.06 (d, J=4.5 Hz, 3H), 1.46 (s, 6H). MS (ESI) m/e 270 (M+H)+.
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