Chlorosuccinimide → 1-(2-Amino-5-bromo-3-chlorophenyl)ethanone
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Cl:12]N1C(=O)CCC1=O>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Cl:12])=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]参加物
4
実験手順
To a solution of 1-(2-amino-5-bromophenyl)ethanone (200 mg, 0.93 mmol) in CH2Cl2 (5 mL) was added N-chlorosuccinimide (125 mg, 0.93 mmol). The mixture was stirred at room temperature overnight. Analysis indicated that the reaction was incomplete; therefore, additional N-chlorosuccinimide (125 mg, 0.93 mmol) was added and the mixture was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue was purified by CombiFlash (40 g column, 0-10% EtOAc/heptane) to afford 1-(2-amino-5-bromo-3-chlorophenyl)ethanone (206 mg, 89%).
後処理
- stirringthe mixture was stirred at room temperature overnight
- customThe solvents were removed under reduced pressure
- customthe residue was purified by CombiFlash (40 g column, 0-10% EtOAc/heptane)
出典と根拠
- ORDレコード
- ord-2a9c91df13614deea504ccdadffb74a3
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318762B2
反応ノート
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