Sulfuric Acid → HCID 178434328、化合物
反応式
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[C:10](=O)[CH3:11].OS(O)(=O)=O.[N:18]([O-])=O.[Na+].O.O.Cl[Sn]Cl>O>[Br:9][C:5]1[CH:4]=[C:3]2[C:2](=[C:7]([Cl:8])[CH:6]=1)[NH:1][N:18]=[C:10]2[CH3:11]参加物
6
実験手順
To a 0° C. solution of 1-(2-amino-5-bromo-3-chlorophenyl)ethanone (206 mg, 0.83 mmol) in 50% aqueous solution of concentrated H2SO4 was slowly added NaNO2 (73 mg, 1.0 mmol). The cooling bath was removed following the addition of NaNO2, stirred at room temperature for 1 hour and then recooled to 0° C. before addition of SnCl2.2H2O (573 mg, 2.49 mmol). The mixture was stirred at 0° C. for 1 hour before dilution with water. The solids were collected by vacuum filtration to afford 5-bromo-7-chloro-3-methyl-1H-indazole (130 mg, 64%).
後処理
- customTo a 0° C.
- customThe cooling bath was removed
- additionthe addition of NaNO2
- filtrationThe solids were collected by vacuum filtration
出典と根拠
- ORDレコード
- ord-4e73020acbb541c3ae3289bec71a9e16
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318762B2
反応ノート
読み込み中…