Chlorosuccinimide → HCID 66920482、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Cl:13]N1C(=O)CCC1=O>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Cl:13])=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11]参加物
4
反応条件
- 温度
- 45 °C
実験手順
1-(2-Amino-5-bromo-phenyl)-propan-1-one (144.0 mg, 0.63 mmol) was dissolved in CH2Cl2 (10.0 mL), and N-chlorosuccinimide (168.0 mg, 1.26 mmol) was added to this solution. The resulting mixture was stirred at 45° C. overnight. The reaction was cooled to room temperature and concentrated. The residue was purified through column chromatography to afford 1-(2-amino-5-bromo-3-chloro-phenyl)-propan-1-one as a solid (130.0 mg, 76.1%).
後処理
- temperatureThe reaction was cooled to room temperature
- concentrationconcentrated
- customThe residue was purified through column chromatography
出典と根拠
- ORDレコード
- ord-6a54147f7a0b4cb984980a24c0921df4
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318762B2
反応ノート
読み込み中…