1-Propanol, 2,2,3,3,3-pentafluoro-1-methoxy- → (4S)-4-isobutyl-2-(pentafluoroethyl)-1,3-oxazolidine
反応式
[CH3:1][O:2][CH:3](O)[C:4]([F:10])([F:9])[C:5]([F:8])([F:7])[F:6].[NH2:12][C@H:13](CO)[CH2:14][CH:15]([CH3:17])[CH3:16]>C1C=CC=CC=1>[CH2:14]([C@H:13]1[CH2:1][O:2][CH:3]([C:4]([F:10])([F:9])[C:5]([F:8])([F:7])[F:6])[NH:12]1)[CH:15]([CH3:17])[CH3:16]参加物
4
実験手順
Pentafluoropropanal methyl hemiacetal (14.9 g, 82.8 mmol) and L-leucinol (9.7 g, 82.8 mmol) were dissolved in 100 mL of benzene and heated to reflux overnight in a flask equipped with a Dean-Stark tube. The resulting solution was cooled and concentrated to provide the title compound as an oil which was used directly in the following step.
後処理
- temperatureheated
- temperatureto reflux overnight in a flask
- customequipped with a Dean-Stark tube
- temperatureThe resulting solution was cooled
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-52023fe94ecb4d4e9d6624e75ae25b38
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318748B2
反応ノート
読み込み中…