4-Fluorobenzaldehyde → (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol
反応式
[NH2:1][C@H:2]([CH2:7][OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1>C1C=CC=CC=1>[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[N:1][C@@H:2]([CH2:3][CH:4]([CH3:6])[CH3:5])[CH2:7][OH:8])=[CH:12][CH:11]=1参加物
4
実験手順
A mixture of (L)-leucinol (1.13 g, 9.67 mmol) and 4-fluorobenzaldehyde (1.20 g, 9.67 mmol) was dissolved in benzene (30 mL) and heated at reflux for 1 hour, using a Dean-Stark apparatus to remove water. (S)-2-[(4-Fluorobenzylidene)-amino]-4-methylpentan-1-ol was isolated by concentration in vacuo, and was used immediately without further purification.
後処理
- temperatureheated
- temperatureat reflux for 1 hour
- customto remove water
出典と根拠
- ORDレコード
- ord-cd780985c64d4e8f8348c8d7039047a9
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318748B2
反応ノート
読み込み中…