2,2-Dimethylbutyryl chloride → 4-(2,2-Dimethylbutanoyl)-3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one

関与物質

反応手順

To 1 ml of pyridine were added 0.3 g of 1,8-diazabicyclo[5,4,0]undec-7-ene, and 0.3 g of 3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one, and 0.26 g of 2,2-dimethylbutanoyl chloride was added at room temperature. After stirring for 3 hours, the resultant solution was concentrated, and the residue was subjected to silica gel column chromatography to obtain 0.24 g of 4-(2,2-dimethylbutanoyl)-3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one (present compound (11)).

情報源と証拠