4-[1-(Trifluoromethyl)ethenyl]pyridine → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine

関与物質

反応手順

To 20 ml of ethyl acetate were added 1.5 g of 4-[1-(trifluoromethyl)ethenyl]pyridine and 0.15 g of 10% Pd/C, and the mixture was stirred under the hydrogen atmosphere for 7 hours. The mixture was filtered, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain 1.3 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine.

情報源と証拠