関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Trimethylsilyl cyanide | HCID 82115 | — |
| 反応物 | 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine | HCID 59570337 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine-2-carbonitrile | HCID 59570359 | — |
反応手順
To 8 ml of acetonitrile were added 0.9 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine=N-oxide, 1.31 ml of triethylamine and 1.4 g of trimethylsilyl cyanide, and the mixture was stirred at 90° C. for 16 hours. Thereafter, the reaction solution was allowed to cool to temperature, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.7 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine-2-carbonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08318776B2 |
|---|
| 出典データセット | uspto-grants-2012_11 |
|---|
| ORD ID | ord-2962d583b9b645e5b8d8ceb44003d091 |
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| 出典メモ | uspto-grants-2012_11 |
|---|
