Acetyl chloride → N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide
反応式
Cl.[NH2:2][CH:3]([C:6]1[C:11]([Cl:12])=[CH:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)[C:4]#[N:5].C(N(CC)CC)C.[C:24](Cl)(=[O:26])[CH3:25]>ClCCl>[Cl:12][C:11]1[C:6]([CH:3]([C:4]#[N:5])[NH:2][C:24](=[O:26])[CH3:25])=[N:7][CH:8]=[C:9]([C:13]([F:15])([F:16])[F:14])[CH:10]=1参加物
5
実験手順
0.67 g of amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride (0.00245 mol) are dissolved in 15 mL of dichloromethane, 0.68 mL of triethylamine are added. After 10 min. at room temperature, 0.18 mL of acetyl chloride (0.00245 mol) are added, the reaction mixture is stirred overnight. The reaction is quenched with 20 mL of water.
後処理
- customThe reaction is quenched with 20 mL of water
出典と根拠
- ORDレコード
- ord-b6bcd0b80cc6470f85a25c3e1b2b416c
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318777B2
反応ノート
読み込み中…