Ethanol → Ethyl 3-(cyclopentylamino)-2-hydroxy-2-methylpropanoate
反応式
[CH3:1][C:2]1([C:5]([O:7][CH3:8])=[O:6])[O:4][CH2:3]1.[CH:9]1([NH2:14])[CH2:13][CH2:12][CH2:11][CH2:10]1.[CH2:15](O)C>>[CH:9]1([NH:14][CH2:3][C:2]([OH:4])([CH3:1])[C:5]([O:7][CH2:8][CH3:15])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of methyl 2-methylglycidate (3.18 g, 27 mmol) and cyclopentylamine (4 mL, 41 mmol) in ethanol (50 mL) was heated at 80° C. for 3 d. The reaction mixture was then concentrated, diluted to EtOAc, washed by NaHCO3, brine and water. Organic layer was dried, concentrated to give a residue which is used for next step without further purification (3.9 g, 60%). [M+H] calc'd for C11H21NO3, 216; found 216.
後処理
- concentrationThe reaction mixture was then concentrated
- additiondiluted to EtOAc
- washwashed by NaHCO3, brine and water
- customOrganic layer was dried
- concentrationconcentrated
- customto give a residue which
- customis used for next step without further purification (3.9 g, 60%)
出典と根拠
- ORDレコード
- ord-79d8aeff0d07427b9c2a5907fa94c044
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318727B2
反応ノート
読み込み中…