Acetic Acid → 4-Amino-3-fluoro-5-methoxybenzoic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:14][CH3:15])[C:10]=1[N+:11]([O-])=O)[C:5]([OH:7])=[O:6].CC(O)=O.[H][H]>CO>[NH2:11][C:10]1[C:9]([O:14][CH3:15])=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=1[F:1]参加物
5
実験手順
A solution of 3-fluoro-5-methoxy-4-nitrobenzoic acid (obtained above), HOAc (5 mL) and MeOH (5 mL) was hydrogenated using a hydrogen balloon overnight. The solution was then filtered through celite and concentrated to a red solid (590 mg, 66%). [M+H] calc'd for C8H8FNO3, 186; found 186.
後処理
- filtrationThe solution was then filtered through celite
- concentrationconcentrated to a red solid (590 mg, 66%)
出典と根拠
- ORDレコード
- ord-e031b782645449e59b532a8bd890201f
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318727B2
反応ノート
読み込み中…