3-Fluoro-4-(4-methylpiperazin-1-yl)aniline → 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-2-fluoro-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-5-methoxybenzamide
反応式
[CH:1]1([N:6]2[CH2:12][C:11]([F:14])([F:13])[C:10](=[O:15])[N:9]([CH3:16])[C:8]3[CH:17]=[N:18][C:19]([NH:21][C:22]4[C:30]([O:31][CH3:32])=[CH:29][C:25]([C:26]([OH:28])=O)=[C:24]([F:33])[CH:23]=4)=[N:20][C:7]2=3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:34][C:35]1[CH:36]=[C:37]([CH:39]=[CH:40][C:41]=1[N:42]1[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]1)[NH2:38]>>[CH:1]1([N:6]2[CH2:12][C:11]([F:14])([F:13])[C:10](=[O:15])[N:9]([CH3:16])[C:8]3[CH:17]=[N:18][C:19]([NH:21][C:22]4[C:30]([O:31][CH3:32])=[CH:29][C:25]([C:26]([NH:38][C:37]5[CH:39]=[CH:40][C:41]([N:42]6[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]6)=[C:35]([F:34])[CH:36]=5)=[O:28])=[C:24]([F:33])[CH:23]=4)=[N:20][C:7]2=3)[CH2:2][CH2:3][CH2:4][CH2:5]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared in a manner analogous to compound 149 from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoic acid and 3-fluoro-4-(4-methylpiperazin-1-yl)aniline with yield 70 mg (53%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.42-1.73 (m, 6 H) 1.86-2.06 (m, 2 H) 2.22 (s, 3 H) 2.35-2.49 (m, 4 H) 2.97 (br. s., 4 H) 3.94 (s, 3 H) 4.09 (t, J=13.89 Hz, 2 H) 4.82 (t, J=7.83 Hz, 1 H) 7.01 (t, J=9.35 Hz, 1 H) 7.26 (d, J=6.82 Hz, 1 H) 7.32-7.45 (m, 1 H) 7.63 (dd, J=15.03, 1.89 Hz, 1 H) 8.10 (s, 1 H) 8.19-8.46 (m, 2 H) 10.16 (s, 1 H). [M+H] calc'd for C32H36F4N8O3, 657; found 657.
出典と根拠
- ORDレコード
- ord-70afa0b4ec8b4e2aa37a10bc62ea124f
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318727B2
反応ノート
読み込み中…