Methanol → 4-(4-Hydroxyphenyl)butanoic acid methyl ester

The 4-(4-hydroxyphenyl)butanoic acid (1) (4.6 g) from the previous step was dissolved in methanol (60 mL), concentrated sulfuric acid (1 mL) was added, and refluxed by heating for two days. The reaction solution was poured into water, and extracted with ethyl acetate (200 mL). The organic layer was washed with water (50 mL), saturated aqueous solution of sodium hydrogen carbonate (50 mL) and saturated sodium chloride solution (50 mL). After drying on anhydrous sodium sulfate, filtration and vacuum concentration, the above-identified compound (4.9 g, yield 99%) was obtained.

1. temperaturerefluxed
2. temperatureby heating for two days
3. extractionextracted with ethyl acetate (200 mL)
4. washThe organic layer was washed with water (50 mL), saturated aqueous solution of sodium hydrogen carbonate (50 mL) and saturated sodium chloride solution (50 mL)
5. dry with materialAfter drying on anhydrous sodium sulfate, filtration and vacuum concentration

ORDレコード

ord-ddabfb4001e74cad8d406a525cc3f8be

出典データセット

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08318781B2