Hydrochloric Acid → 5-Ethoxy-4-hydroxy-2-nitrobenzaldehyde

HRID 1881185ノート

反応式

HRID 1881185 の反応式
C([O:8][C:9]1[C:16]([O:17][CH2:18][CH3:19])=[CH:15][C:12]([CH:13]=[O:14])=[C:11]([N+:20]([O-:22])=[O:21])[CH:10]=1)C1C=CC=CC=1.Cl>C(O)(=O)C>[CH2:18]([O:17][C:16]1[C:9]([OH:8])=[CH:10][C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:15]=1)[CH:13]=[O:14])[CH3:19]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 123199814-(Benzyloxy)-5-ethoxy-2-nitrobenzaldehyde

生成物 1

HCID 450942415-Ethoxy-4-hydroxy-2-nitrobenzaldehyde

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

4-Benzyloxy-5-ethoxy-2-nitro-benzaldehyde (23 g) was dissolved in acetic acid (93 ml) and concentrated hydrochloric acid (10 ml). The reaction solution was refluxed for 24 hours. Then the solution was evaporated to dryness and the residue was dissolved in diethyl ether. The product was extracted into 1M sodium hydroxide and acidified with 6M hydrochloric acid. The resultant solid was filtered and dried under vacuum.

後処理

  1. temperatureThe reaction solution was refluxed for 24 hours
  2. customThen the solution was evaporated to dryness
  3. dissolutionthe residue was dissolved in diethyl ether
  4. extractionThe product was extracted into 1M sodium hydroxide
  5. filtrationThe resultant solid was filtered
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-a9c9a02e0f0d408dae6ca5b55dcb5a39
出典データセット
uspto-grants-2012_11
特許番号
US08318785B2

反応ノート

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