Potassium Carbonate → 2-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide

HRID 1881337ノート

反応式

HRID 1881337 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N+:3]=1[O-:10].[NH:11]1[CH2:15][CH2:14][C@H:13]2[CH2:16][N:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][C@@H:12]12.C([O-])([O-])=O.[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:11]2[CH2:15][CH2:14][C@H:13]3[CH2:16][N:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][C@@H:12]23)=[CH:4][N+:3]=1[O-:10]

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 124874662-Chloro-5-chloromethylpyridine 1-oxideHCID 43604250(3AS,6AS)-5-Ethoxycarbonyl-1H-hexahydropyrrolo[3,4-B]pyrrole

生成物 1

HCID 866495632-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide

実験手順

The titled compound was prepared in analogy to examples 2.2 and 2.3 using 2-chloro-5-(chloromethyl)pyridine 1-oxide (712 mg, 4 mmol), (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (1.1 g, 5.97 mmol), and K2CO3 (553 mg, 4 mmol). The obtained crude product was used without further purification in the next reaction step.

後処理

  1. customThe obtained crude product
  2. customwas used without further purification in the next reaction step

出典と根拠

ORDレコード
ord-f6a1690384fd4803bf3d8e4e07014a2f
出典データセット
uspto-grants-2012_11
特許番号
US08318793B2

反応ノート

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