Phosphorus trichloride → (3aS,6aS)-Ethyl 1-((6-(5-cyano-2-hydroxy-1H-indol-3-yl)pyridin-3-yl)methyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

HRID 1881339ノート

反応式

HRID 1881339 の反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([OH:12])=[C:6]2[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][N:20]2[CH2:24][CH2:23][C@H:22]3[CH2:25][N:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:27][C@@H:21]23)=[CH:15][N+:14]=1[O-])#[N:2].P(Cl)(Cl)Cl>>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([OH:12])=[C:6]2[C:13]1[N:14]=[CH:15][C:16]([CH2:19][N:20]2[CH2:24][CH2:23][C@H:22]3[CH2:25][N:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:27][C@@H:21]23)=[CH:17][CH:18]=1)#[N:2]

参加物

3

反応物 2

HCID 24387Phosphorus trichlorideHCID 178473354HCID 178473354、化合物

生成物 1

HCID 136414313(3aS,6aS)-Ethyl 1-((6-(5-cyano-2-hydroxy-1H-indol-3-yl)pyridin-3-yl)methyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

実験手順

The titled compound was prepared in analogy to example 4.2 starting from 2-(5-cyano-2-hydroxy-1H-indol-3-yl)-5-(((3aS,6aS)-5-(ethoxy-carbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide (100 mg) and phosphorus trichloride (123 mg). The obtained crude product was used without further purification in the next reaction step.

後処理

  1. customThe obtained crude product
  2. customwas used without further purification in the next reaction step

出典と根拠

ORDレコード
ord-f836f0a2f3284415a2eeb6b9b08ed583
出典データセット
uspto-grants-2012_11
特許番号
US08318793B2

反応ノート

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