1,1'-Thiocarbonyldiimidazole → 5-Isothiocyanato-indan-2-ol

HRID 1881355ノート

反応式

HRID 1881355 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([OH:11])[CH2:5]2.C1N=CN([C:17](N2C=NC=C2)=[S:18])C=1>C(Cl)Cl>[N:1]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([OH:11])[CH2:5]2)=[C:17]=[S:18]

参加物

4

反応物 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 215550315-amino-2,3-dihydro-1H-inden-2-ol

生成物 1

HCID 866197015-Isothiocyanato-indan-2-ol収率 69%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5-Amino-indan-2-ol (149 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and TCDI (thiocarbodiimidazole, 178 mg, 1 mmol) was added to the solution. The reaction mixture was stirred at room temperature for 30 min. Silica gel was added to the reaction mixture and dried. Purification of silica gel coated crude product by column chromatography (EtOAc:Hexane=3:7) afforded the title product as a white solid (132 mg).

後処理

  1. additionSilica gel was added to the reaction mixture
  2. customdried
  3. customPurification of silica gel coated crude product by column chromatography (EtOAc:Hexane=3:7)

出典と根拠

ORDレコード
ord-8573e09a03784c55aa6bd940d12e446a
出典データセット
uspto-grants-2012_11
特許番号
US08318790B2

反応ノート

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