1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone → 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid

HRID 1881646ノート

反応式

HRID 1881646 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14](=O)[CH3:15])[C:9]=2[OH:17])=[CH:4][CH:3]=1.[NH:18]([C:20]([NH:22][C:23]1[S:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][CH:24]=1)=[S:21])[NH2:19]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14](=[N:19][NH:18][C:20]([NH:22][C:23]3[S:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][CH:24]=3)=[S:21])[CH3:15])[C:9]=2[OH:17])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 670501011-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanoneHCID 860144975-Hydrazinocabonothioylamino-2-thiophenecarboxylic acid

生成物 1

HCID 723600695-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid

実験手順

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.0 mg, yield 83%).

出典と根拠

ORDレコード
ord-e960a0fc69594542a8f4b0e1efd9c99b
出典データセット
uspto-grants-2012_11
特許番号
US08318796B2

反応ノート

読み込み中…