1-[5-(4-Chlorophenyl)-4-hydroxythiophen-3-yl]ethan-1-one → 5-{[(2-{1-[5-(4-Chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid

HRID 1881649ノート

反応式

HRID 1881649 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([C:14]([CH3:16])=O)[C:12]=2[OH:13])=[CH:4][CH:3]=1.[NH:17]([C:19]([NH:21][C:22]1[S:26][C:25]([C:27]([OH:29])=[O:28])=[CH:24][CH:23]=1)=[S:20])[NH2:18]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([C:14](=[N:18][NH:17][C:19]([NH:21][C:22]3[S:26][C:25]([C:27]([OH:29])=[O:28])=[CH:24][CH:23]=3)=[S:20])[CH3:16])[C:12]=2[OH:13])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 442072911-[5-(4-Chlorophenyl)-4-hydroxythiophen-3-yl]ethan-1-oneHCID 860144975-Hydrazinocabonothioylamino-2-thiophenecarboxylic acid

生成物 1

HCID 723600345-{[(2-{1-[5-(4-Chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid

実験手順

From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.3 mg, 0.10 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (21.8 mg, 0.10 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (37.1 mg, yield 82%).

出典と根拠

ORDレコード
ord-989e050c522f4633bb378aff66bd49cc
出典データセット
uspto-grants-2012_11
特許番号
US08318796B2

反応ノート

読み込み中…