Acetyl chloride → Methyl 4-(piperidin-2-yl)butanoate hydrochloride

HRID 1881682ノート

反応式

HRID 1881682 の反応式
C([Cl:4])(=O)C.[CH3:5][O:6][C:7](=[O:24])[CH2:8][CH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N:12]1C(OC(C)(C)C)=O>CO>[ClH:4].[NH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH:11]1[CH2:10][CH2:9][CH2:8][C:7]([O:6][CH3:5])=[O:24]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 57904248Tert-butyl 2-(4-methoxy-4-oxobutyl)piperidine-1-carboxylate

生成物 1

HCID 66772062Methyl 4-(piperidin-2-yl)butanoate hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Acetyl chloride was slowly added dropwise to a solution of tert-butyl 2-(4-methoxy-4-oxobutyl)piperidine-1-carboxylate (3) (25.67 g, 89.9 mmol) in methanol. The reaction mixture was stirred at room temperature for 5 h. The complete reaction was checked by means of TLC. When the reaction was complete, the reaction mixture was concentrated under reduced pressure to obtain methyl 4-(piperidine-2-yl)butanoate hydrochloride (4) (20.14 g, 100%).

後処理

  1. customThe complete reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3609fd042a8b433fad0ebe890b2cccec
出典データセット
uspto-grants-2012_11
特許番号
US08318769B2

反応ノート

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