HCID 25234930、化合物 → Apricitabine
反応式
C([O:9][CH2:10][C@H:11]1[S:15][C@@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH:21]C(=O)C3C=CC=CC=3)=[N:19][C:17]2=[O:18])[CH2:13][O:12]1)(=O)C1C=CC=CC=1>N>[OH:9][CH2:10][C@H:11]1[S:15][C@@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:13][O:12]1参加物
3
試薬・触媒・溶媒 1
実験手順
2-(R)-benzoyloxymethyl-4-(R)—(N-benzoylcytosin-1-yl)-1,3-oxathiolane (15 g, 0.028 mol) was dissolved in a methanolic ammonia (approximately 2M) solution (250 mL). The initial slurry was stirred overnight. After overnight stirring, the resulting clear solution was filtered through celite, evaporated to dryness and slurried in acetone (100 mL). This yielded off-white powdery solid which was filtered and washed with acetone (2×25 mL), and dried to yield the product. 6.5 g (94%).
後処理
- stirringAfter overnight stirring
- filtrationthe resulting clear solution was filtered through celite
- customevaporated to dryness
- filtrationThis yielded off-white powdery solid which was filtered
- washwashed with acetone (2×25 mL)
- customdried
- customto yield the product
出典と根拠
- ORDレコード
- ord-8dc363a5b27a4881b04796ad5fefc4e5
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318934B2
反応ノート
読み込み中…