HCID 25234931、化合物 → Apricitabine, (+)-

HRID 1881706ノート

反応式

HRID 1881706 の反応式
C([O:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH:21]C(=O)C3C=CC=CC=3)=[N:19][C:17]2=[O:18])[CH2:13][O:12]1)(=O)C1C=CC=CC=1>N>[OH:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:13][O:12]1

参加物

3

反応物 1

HCID 25234931HCID 25234931、化合物

生成物 1

HCID 468214Apricitabine, (+)-

試薬・触媒・溶媒 1

HCID 222Ammonia溶媒

実験手順

2-(S)-benzoyloxymethyl-4-(S)—(N-benzoylcytosin-1-yl)-1,3-oxathiolane (1.0 g, 0.0022 mol) was dissolved in a methanolic ammonia (approximately 2M) solution (20 mL). The initial slurry was stirred overnight. After overnight stirring, the resulting clear solution was evaporated to dryness and slurried in acetone (20 mL). This yielded off-white powdery solid which was filtered and washed with acetone (2×10 mL), and dried to yield the product. 0.47 g (88%).

後処理

  1. stirringAfter overnight stirring
  2. customthe resulting clear solution was evaporated to dryness
  3. filtrationThis yielded off-white powdery solid which was filtered
  4. washwashed with acetone (2×10 mL)
  5. customdried
  6. customto yield the product

出典と根拠

ORDレコード
ord-6b36288fdd60451b99de7292bb93f010
出典データセット
uspto-grants-2012_11
特許番号
US08318934B2

反応ノート

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