2,4-Diisopropylphenol → 2-Bromo4,6-diisopropyl-phenol
反応式
[CH:1]([C:4]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[OH:13])([CH3:3])[CH3:2].[Br:14]Br>C(O)(=O)C>[Br:14][C:6]1[CH:7]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5]=1[OH:13]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of 2,4-diisopropyl-phenol (Intermediate 1, 10.0 g, 56 mmol) in acetic acid (20 mL) was added bromine (3.5 mL, 67 mmol) at 0° C. The mixture was stirred at 0° C. for 15 min, quenched with water and extracted with EtOAc. The organic layer was washed successively with NaOH (4M, 85 mL), NaHSO3, and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (hexanes) to yield the title compound as a light yellow oil (14.5 g, 100%).
後処理
- customquenched with water
- extractionextracted with EtOAc
- washThe organic layer was washed successively with NaOH (4M, 85 mL), NaHSO3, and brine
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
- customThe residue was purified by flash column chromatography on silica gel (hexanes)
出典と根拠
- ORDレコード
- ord-40b8d677d3ff45379c297e1dbb08aba4
- 出典データセット
- uspto-grants-2004_07
- 特許番号
- US06759546B1
反応ノート
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