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Hexylamine → [2-(Hexylamino)phenyl]methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexylamine | HCID 8102 | — |
| 反応物 | 2-Bromobenzyl alcohol | HCID 72850 | — |
| 生成物 | [2-(Hexylamino)phenyl]methanol | HCID 15084054 | 81% |
反応手順
Using the general procedure, 2-bromobenzyl alcohol (187 mg, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol) at 90° C. for 22 h. Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (6:1) as eluent afforded the desired product as a colorless liquid (168 mg, 81% yield). Rf=0.7 (hexane/ethyl acetate=2:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06759554B2 |
| 出典データセット | uspto-grants-2004_07 |
| ORD ID | ord-687dd388084749118e1149474476f5de |
| 出典メモ | uspto-grants-2004_07 |