HCID 23508505、化合物 → HCID 23508424、化合物

HRID 1883670ノート

反応式

HRID 1883670 の反応式
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24]CC3C=CC=CC=3)=[CH:20][CH:19]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[H][H]>[C].[Pd].O1CCOCC1>[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:3])=[O:4]

参加物

5

反応物 2

HCID 23508505HCID 23508505、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 23508424HCID 23508424、化合物収率 92.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture composed of 350 mg of 4-[N-(4-benzyloxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate, 350 mg of 10% palladium-carbon, and 10 ml of dioxane was stirred for 2 days under an atmospheric pressure of hydrogen. The reaction mixture was filtered to remove any insoluble matter, and the solvent was distilled off from the filtrate. Thus, there was obtained 260 mg of 4-[N-(4-hydroxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customto remove any insoluble matter
  3. distillationthe solvent was distilled off from the filtrate

出典と根拠

ORDレコード
ord-e709158e422a405eaf229008c5119fb2
出典データセット
uspto-grants-2004_07
特許番号
US06762205B1

反応ノート

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