Hydrochloric Acid → N-(4-tert-butyldimethylsilyloxybenzyl)-N-(4-cyanophenyl)-2-thiophenecarboxamide

HRID 1883694ノート

反応式

HRID 1883694 の反応式
[Si:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][NH:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[S:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30](Cl)=[O:31].Cl>>[Si:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][N:14]([C:15]2[CH:16]=[CH:17][C:18]([C:19]#[N:20])=[CH:21][CH:22]=2)[C:30]([C:26]2[S:25][CH:29]=[CH:28][CH:27]=2)=[O:31])=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 789282-Thiophenecarbonyl chlorideHCID 235083944-[N-(4-tert-butyldimethylsilyloxybenzyl)amino]benzonitrile

生成物 1

HCID 23508393N-(4-tert-butyldimethylsilyloxybenzyl)-N-(4-cyanophenyl)-2-thiophenecarboxamide収率 76.2%

実験手順

The procedure of Preparation Example 8 was repeated, except that 195 mg of 4-[N-(4-tert-butyldimethylsilyloxybenzyl)amino]benzonitrile was used in place of 4-[N-(4-benzyloxybenzyl)amino]phenol, and 84 mg of 2-thiophenecarbonyl chloride was used in place of methanesulfonyl chloride. The resulting mixture was stirred at room temperature for 19 hours. After the reaction mixture was poured into dilute hydrochloric acid, the product was extracted with ethyl acetate. After the extract was successively washed with a saturated aqueous solution of sodium hydrogen carbonate and a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The resulting crude product was purified by TLC (using a 3:1 mixture of hexane and ethyl acetate as the developing solvent) to obtain 196 mg of N-(4-tert-butyldimethylsilyloxybenzyl)-N-(4-cyanophenyl)-2-thiophenecarboxamide.

後処理

  1. customThe procedure of Preparation Example 8
  2. extractionthe product was extracted with ethyl acetate
  3. washAfter the extract was successively washed with a saturated aqueous solution of sodium hydrogen carbonate
  4. dry with materiala saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure
  6. customThe resulting crude product was purified by TLC (
  7. additiona 3:1 mixture of hexane and ethyl acetate as the developing solvent)

出典と根拠

ORDレコード
ord-f0d29c8978b44656b6fbfd0b3337eced
出典データセット
uspto-grants-2004_07
特許番号
US06762205B1

反応ノート

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