(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile → 92497-66-0

HRID 1883703ノート

反応式

HRID 1883703 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6](/[C:9](=[CH:12]/[C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)/[C:10]#[N:11])=[CH:5][CH:4]=1>ClCCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6](/[C:9](=[CH:12]/[C:13]2[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=2)/[C:10]#[N:11])=[CH:5][CH:4]=1

参加物

3

反応物 1

HCID 5716814(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile

生成物 1

HCID 630336292497-66-0収率 64.9%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

The procedure of Preparation Example 2 was repeated, except that 224 mg of (2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile was used in place of 4′-methoxy-2-biphenylacetonitrile, and 1,2-dichloroethane was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 3:1 mixture of chloroform and acetone as the developing solvent) to obtain 130 mg of (2Z)-2,3-bis(4-hydroxyphenyl)-prop-2-enenitrile.

後処理

  1. customThe procedure of Preparation Example 2
  2. customThe resulting crude product was purified by TLC (
  3. additiona 3:1 mixture of chloroform and acetone as the developing solvent)

出典と根拠

ORDレコード
ord-a6d7a8adb684455c8c7f7787a0305578
出典データセット
uspto-grants-2004_07
特許番号
US06762205B1

反応ノート

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