Ammonium Hydroxide → N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamide

反応式

C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)=[O:6].[OH-].[NH4+:28]>>[F:23][C:22]([F:25])([F:24])[C:19]1[CH:20]=[CH:21][C:16]([CH2:15][O:14][C:11]2[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:28])=[O:2])=[CH:9][CH:10]=2)=[CH:17][CH:18]=1

参加物

反応物 2

HCID 14923Ammonium Hydroxide

HCID 69007555N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

生成物 1

HCID 22137944N-[4-(4-Trifluoromethyl-benzyloxy)-phenyl]-malonamide収率 65%

実験手順

The title compound is prepared in analogy to example 3 from N-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-malonamic acid methyl ester and ammonium hydroxide. Yield=65%. Colorless solid. MS: m/e=353.1 (M++H).

出典と根拠

ORDレコード: ord-4d3030bcc3c94eaab27fdefaa22641dc
出典データセット: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06762320B2

反応ノート

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