関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Acetophenone | HCID 7410 | — |
| 反応物 | Ethylbenzene | HCID 7500 | — |
| 反応物 | N-Hydroxyphthalimide | HCID 10665 | — |
| 反応物 | Tert-Butyl nitrite | HCID 10906 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-Nitroethylbenzene | HCID 23618 | — |
| 反応物 | Acetophenonoxime | HCID 69185 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-Phenylethyl Acetate | HCID 62341 | — |
反応手順
Ethylbenzene (2 ml), t-butyl nitrite (4 mmol), N-hydroxyphthalimide (0.4 mmol), and acetic acid (2 ml) were placed in a flask and were stirred at 80° C. in an atmosphere of argon gas for 2.5 hours. The resulting mixture was further treated with sulfuric acid having a concentration of 98% by weight (200 mg) with stirring at 70° C. for 15 minutes. The reaction mixture was then neutralized with sodium hydroxide and was analyzed to find that acetophenone oxime, (1-nitroethyl)benzene, acetophenone, and α-methylbenzyl acetate were formed in yields of 61%, 1%, 8%, and 5%, respectively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06768023B2 |
|---|
| 出典データセット | uspto-grants-2004_07 |
|---|
| ORD ID | ord-f44d2a595cbf495c8f576e7c30ced97c |
|---|
| 出典メモ | uspto-grants-2004_07 |
|---|
