Sodium Methoxide → 3,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

HRID 1885650ノート

反応式

HRID 1885650 の反応式
Br[C:2]([CH3:18])([CH3:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[O:4].[CH3:19][O-:20].[Na+]>CO>[CH3:17][C:2]1([CH3:18])[O:4][C:3]1([O:20][CH3:19])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 198795192-Bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one

生成物 1

HCID 198794483,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

12.0 g (38.7 mmol) of 2-bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one are dissolved in 20 ml of methanol, and 7.0 g (46.4 mmol) of methanolic 30% strength sodium methylate solution are then added dropwise at room temperature. The methanol is then distilled off under reduced pressure. The residue is taken up in toluene, and the precipitated salt is filtered off. The solution is concentrated in vacuo. The brown residue, which is a slowly crystallising liquid, is directly further reacted.

後処理

  1. distillationThe methanol is then distilled off under reduced pressure
  2. filtrationthe precipitated salt is filtered off
  3. concentrationThe solution is concentrated in vacuo
  4. customa slowly crystallising liquid

出典と根拠

ORDレコード
ord-8565dac0cd8148fa90b713f6184f8691
出典データセット
uspto-grants-1992_09
特許番号
US05145885

反応ノート

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