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Sulfuric Acid → Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Phenylacetonitrile | HCID 8794 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 反応物 | Phenylacetate | HCID 4409936 | — |
| 反応物 | {[2-(Methoxycarbonyl)phenyl]methyl}(triphenyl)phosphanium bromide | HCID 10743695 | — |
| 反応物 | Methyl 2-[2-(2-furyl)ethyl]phenylacetate | HCID 19879669 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate | HCID 19879670 | — |
反応手順
Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate was prepared from 4-fluorobenzaldehyde and (o-methoxycarbonylbenzyl)triphenylphosphonium bromide by a route similar to that described in Example 3 for the preparation of methyl 2-[2-(2-furyl)ethyl]phenylacetate. In this instance, the benzyl chloride was converted into the phenylacetate by treatment with potassium cyanide in DMSO and, then, methanolysis of the resulting phenylacetonitrile with sulphuric acid in methanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05145954 |
| 出典データセット | uspto-grants-1992_09 |
| ORD ID | ord-51a733eb0d084f3f86d134e975174bbe |
| 出典メモ | uspto-grants-1992_09 |