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Trifluoroacetic acid → 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine | HCID 353442 | — |
| 反応物 | 2-(Trifluoromethyl)acrylic acid | HCID 587694 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid | HCID 19691367 | — |
反応手順
A 2.48 g sample of 2-(trifluoromethyl)acrylic acid was dissolved in 40 mL of dry methylene chloride, and a solution of 4.75 g of N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine in 20 mL of dry methylene chloride was added dropwise under N2 at 0° C. To this mixture was added 2 mL of trifluoroacetic acid, and the mixture was stirred for 2 hours at room temperature. The product was removed by filtration, washed and dried to give the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726182 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-7b48bd4f78a1409eb2c2a20f041bf0c4 |
| 出典メモ | uspto-grants-1998_03 |