1,6-Dibromohexane → HCID 19876761、化合物
反応式
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][CH2:8][OH:9])[N:6]=1.[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br>O>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:9][CH2:8][CH2:7][C:5]1[N:6]=[C:2]([CH3:1])[S:3][CH:4]=1参加物
4
実験手順
A mixture of 2-methyl-4-thiazoleethanol (2.22 g), 1,6-dibromohexane (7.1 ml) 12.5M aqueous sodium hydroxide (4 ml) and TAB (0.1 g) was stirred rapidly at room temperature for 16 h. The reaction mixture was diluted with water (30 ml), extracted with ether (3×30 ml) and the combined organic extracts were washed with water (30 ml) and brine (30 ml), dried and concentrated. The residual oil was purified by FCC eluting with diethyl ether-hexane (1:3) to give the title compound as an orange oil (2.21 g), t.l.c. (ether-hexane 1:3) Rf 0.17
後処理
- extractionextracted with ether (3×30 ml)
- washthe combined organic extracts were washed with water (30 ml) and brine (30 ml)
- customdried
- concentrationconcentrated
- customThe residual oil was purified by FCC
- washeluting with diethyl ether-hexane (1:3)
出典と根拠
- ORDレコード
- ord-61af359a52464286bebb9a9858be5a41
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05149698
反応ノート
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