HCID 19876796、化合物 → 1,2-Ethanediamine, N-2-quinolinyl-
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH:11][CH2:12][CH2:13][NH:14]C(=O)C>Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH:11][CH2:12][CH2:13][NH2:14]参加物
3
実験手順
A solution of N-[2-[(quinolin-2-yl)amino]ethyl]acetamide (6.8 g, 0.030 mol) in 2N HCl (45 ml, 0.090 ml) was heated under reflux for 20 hours. The solution was cooled and extracted with EtOAc. The aqueous phase was made basic (pH9) with solid KOH, saturated with NaCl, and extracted with EtOAc. The combined extracts were dried (MgSO4) and concentrated to give 3.89 g (68%) of an off-white solid m.p. 124°-125° C.
後処理
- temperatureunder reflux for 20 hours
- temperatureThe solution was cooled
- extractionextracted with EtOAc
- extractionsaturated with NaCl, and extracted with EtOAc
- dry with materialThe combined extracts were dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8d4e3c17bbda42e5a06a8db5eacf995f
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05149700
反応ノート
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