Quinoxalin-6-ylmethanol → Quinoxaline-6-carboxaldehyde

HRID 1886339

反応式

HRID 1886339 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][OH:12])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1>[O-2].[Mn+4].[O-2].ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]=[O:12])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 6422829Quinoxalin-6-ylmethanol

生成物 1

HCID 763958Quinoxaline-6-carboxaldehyde収率 67.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 10 parts of intermediate 5, namely 6-quinoxalinemethanol in 133 parts of dichloromethane were added 20 parts of manganese(IV) oxide. After stirring for 3 hours at room temperature, the reaction mixture was filtered and the filtrate was evaporated, yielding 6.6 parts (67.3%) of 6-quinoxalinecarboxaldehyde; mp. 134° C. (interm. 6).

後処理

  1. filtrationthe reaction mixture was filtered
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-f4b0bf20122f46e99cbe24fc4184fb9d
出典データセット
uspto-grants-1992_09
特許番号
US05151421

関連ノート

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