Hydrochloric Acid → Ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate

HRID 1886898ノート

反応式

HRID 1886898 の反応式
[CH2:1]([Mg]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([C:12](=[C:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])#[N:11].Cl>C(OCC)C>[CH2:1]([C:18]1([CH:12]([C:10]#[N:11])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 81256Ethyl cyanocyclohexylideneacetateHCID 178418336HCID 178418336、化合物

生成物 1

HCID 14435569Ethyl 2-(1-benzylcyclohexyl)-2-cyanoacetate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

1 M Benzylmagnesium chloride in diethyl ether (18.92 ml) was added dropwise to ethyl 2-cyano-2-cyclohexylideneacetate (1.828 g, 9.46 mmol) in diethyl ether (6.31 ml) at 23° C. The mixture was stirred at room temperature for 3 days. Then 10% hydrochloric acid (7.83 ml, 255 mmol) was added dropwise at 0° C. while stirring. The organic layer was separated, washed with water, dried over Na2SO4, filtered, and concentrated.

後処理

  1. stirringwhile stirring
  2. customThe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-38c9284ead934dc5b600d20cbdad8608
出典データセット
uspto-grants-2013_08
特許番号
US08501722B2

反応ノート

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