化工社化工社 化学情報印刷レポート · 研究参考用
Trimethylamine → 1-benzyl-3-(BOC-amino)-3-trifluoromethylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylamine | HCID 1146 | — |
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 反応物 | 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid | HCID 19691367 | — |
| 生成物 | 1-benzyl-3-(BOC-amino)-3-trifluoromethylpyrrolidine | HCID 19691488 | 96.7% |
反応手順
A mixture of 1.42 g of the compound from step 454a, 1.71 g of diphenylphosphoryl azide, 12.3 g of t-butanol and 0.627 g of trimethyl amine was heated at reflux under N2 for 24 hours. The mixture was concentrated to dryness, and the residue was dissolved in methylene chloride. The solution was washed with satd. NaHCO3 and water, then concentrated. The residue was chromatographed on silica gel to give 1.73 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726182 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3c14aa7c3cf94af8afc09046f03b475b |
| 出典メモ | uspto-grants-1998_03 |