4-(Chloromethyl)-1,3-thiazole → N-Benzyl-4-methyl-2-(2-oxo-4-(thiazol-4-ylmethoxy)pyridin-1(2H)-yl)thiazole-5-carboxamide
反応式
Cl[CH2:2][C:3]1[N:4]=[CH:5][S:6][CH:7]=1.[CH2:8]([NH:15][C:16]([C:18]1[S:22][C:21]([N:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][C:24]2=[O:30])=[N:20][C:19]=1[CH3:31])=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:8]([NH:15][C:16]([C:18]1[S:22][C:21]([N:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:2][C:3]3[N:4]=[CH:5][S:6][CH:7]=3)=[CH:25][C:24]2=[O:30])=[N:20][C:19]=1[CH3:31])=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
3
実験手順
Following the procedure as described in Example 21, making variation only as required to use 4-(chloromethyl)thiazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 29% yield: 1H NMR (300 MHz, DMSO-d6) δ 9.12 (d, J=1.9 Hz, 1H), 8.79 (t, J=5.9 Hz, 1H), 8.61 (d, J=8.0 Hz, 1H), 7.89 (d, J=1.9 Hz, 1H), 7.33-7.27 (m, 4H), 7.25-7.17 (m, 1H), 6.38-6.32 (m, 2H), 5.27 (s, 2H), 4.38 (d, J=5.9 Hz, 2H), 2.54 (s, 3H); MS (ES+) m/z 439.1 (M+1).
出典と根拠
- ORDレコード
- ord-6d2a099fbb5c452bbb90f63d291508b3
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501746B2
反応ノート
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