1,4-Dioxane hydrochloride → HCID 67048907、化合物

反応式

[Br:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@@H:4]2[C@@H:14]([OH:17])[CH2:15][O:16][C@H:3]12.[ClH:18].O1CCOCC1>>[ClH:18].[Br:1][C@H:2]1[CH2:6][NH:5][C@@H:4]2[C@@H:14]([OH:17])[CH2:15][O:16][C@H:3]12

参加物

反応物 2

HCID 204431481,4-Dioxane hydrochloride

HCID 58208606HCID 58208606、化合物

生成物 1

HCID 67048907HCID 67048907、化合物

実験手順

Bromide (111) (2.14 g, 6.95 mmol) was dissolved in 4N HCl/dioxan (30 mL) with stirring at ambient temperature. The purple solution was stirred for 1 hour then reduced in vacuo and evaporated three times from diethyl ether to give a purple crystalline solid crude (3R,3aR,6S,6aS)-6-bromohexahydro-2H-furo[3,2-b]pyrrol-3-ol hydrochloride (112) (Yield 1730 mg) which was used without further purification. HPLC-MS 208.0/210.0 [M+H]+.

後処理

stirringThe purple solution was stirred for 1 hour
customevaporated three times from diethyl ether

出典と根拠

ORDレコード: ord-7e2402a213fd4059ace689a290e1c668
出典データセット: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08501744B2

反応ノート

読み込み中…

参加物