Cesium carbonate → Trifluoroacetic acid

関与物質

役割	名称	HCID	仕込み量
反応物	Cesium carbonate	HCID 10796	—
反応物	2-Methoxy-4-morpholinoaniline	HCID 414960	—
反応物	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
反応物	N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine	HCID 58155070	—
触媒	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
溶媒	1,4-Dioxane	HCID 31275	—
生成物	Trifluoroacetic acid	HCID 6422	—
生成物	N2-(2-methoxy-4-morpholinophenyl)-N4-(pyridin-2-yl)-5-(trifluoromethyl)pyridine-2,4-diamine	HCID 24938452	—

反応手順

Method A was applied to a mixture of N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine (16 mg, 0.059 mmol), 2-methoxy-4-morpholinoaniline (17 mg, 0.082 mmol), Pd2(dba)3 (6 mg, 0.0066 mmol), xantphos (5.5 mg, 0.0095 mmol) and cesium carbonate (43 mg, 0.13 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a yellow solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08501763B2
出典データセット	uspto-grants-2013_08
ORD ID	ord-9359eecd6d9647209b33bfacdc01cf7d
出典メモ	uspto-grants-2013_08