Hydrochloric Acid → Ethanol hydrochloride

HRID 1887720ノート

反応式

HRID 1887720 の反応式
[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1)[NH:9][C:8](=[O:16])[CH:7]([NH:17]C(=O)C)[CH2:6]2>C(O)C>[ClH:1].[CH2:8]([OH:16])[CH3:7].[ClH:1].[NH2:17][CH:7]1[CH2:6][C:5]2[C:10](=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=[C:3]([Br:2])[CH:4]=2)[NH:9][C:8]1=[O:16]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59620398HCID 59620398、化合物

生成物 2

HCID 21887872Ethanol hydrochlorideHCID 684113113-amino-6-bromo-8-nitro-3,4-dihydroquinolin-2(1H)-one hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Aqueous hydrochloric acid-ethanol solution was prepared (from commercial aqueous concentrated hydrochloric acid (3 L) and ethanol (6 L)), and N-(6-bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (known compound: Chem. Abst., 4150 (1947)) (604 g) was added to the solution, followed by heating for 14 hours under stirring and reflux. The reaction mixture was cooled on an ice bath, and the precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and dried, whereby the title compound (571 g) was yielded as a powdery compound.

後処理

  1. additionwas added to the solution
  2. temperatureby heating for 14 hours
  3. temperaturereflux
  4. temperatureThe reaction mixture was cooled on an ice bath
  5. filtrationthe precipitates were recovered through filtration
  6. washThe thus-obtained solid was washed with ethanol
  7. customdried

出典と根拠

ORDレコード
ord-4ecb72a5c49a487caa5283987fb51d63
出典データセット
uspto-grants-2013_08
特許番号
US08501772B2

反応ノート

読み込み中…