Benzyl Bromide → Tert-butyl 1-benzyl-2-oxo-8-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate
反応式
BrCC1C=CSC=1.[CH2:8](Br)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[O:16]=[C:17]1[CH:26]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH2:25][C:24]2[C:19](=[C:20]([N:35]3[CH2:39][CH2:38][CH2:37][C:36]3=[O:40])[CH:21]=[CH:22][CH:23]=2)[NH:18]1>>[CH2:8]([N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][C:20]=2[N:35]2[CH2:39][CH2:38][CH2:37][C:36]2=[O:40])[CH2:25][CH:26]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:31])([CH3:33])[CH3:32])[C:17]1=[O:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
4
実験手順
Instead of 3-bromomethylthiophene, benzylbromide (1.48 mL) was used with respect to tert-butyl 2-oxo-8-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate (Compound B) (4.3 g), which had been produced through the same method as employed in Example 7(a), whereby the title compound (5.87 g) was yielded.