化工社化工社 化学情報印刷レポート · 研究参考用
Donepezil → Donepezil Maleate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Donepezil | HCID 3152 | — |
| 反応物 | Propyl ether | HCID 8114 | — |
| 反応物 | Maleic Acid | HCID 444266 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Donepezil Maleate | HCID 24801486 | — |
反応手順
Maleic acid (1.161 g, dissolved in 10 ml of 2-propanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature followed by adding 10 ml of dipropyl ether. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 126.8° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08501779B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-32da11b15fde4c9cb03ca14a19bc2d79 |
| 出典メモ | uspto-grants-2013_08 |