Ammonia → Flunixin

HRID 1888131

反応式

HRID 1888131 の反応式
[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CS(C1C=CC([C@@H](O)[C@H](NC(C(Cl)Cl)=O)CF)=CC=1)(=O)=O.N>O>[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:20])([F:19])[F:21]

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 56843417Resflor

生成物 1

HCID 38081Flunixin収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

About 300 g of Resflor® is added over about 1 hour to a stirring solution of about 24 mL of concentrated ammonia in about 3 L of water heated to about 50° C. Additional concentrated ammonia can be added to ensure that the pH is about 9. The mixture is stirred and cooled to room temperature. The resulting precipated Florfenicol is removed by filtration. The filtrate is acidifed to about pH 4.5 with 10% H2SO4 then stirred for about another 1 hour. The resulting precipitated Flunixin is collected by filtration then dried to a moisture content of less than about 1% to yield about 4 g of crude Flunixin (100%).

後処理

  1. temperaturecooled to room temperature
  2. customThe resulting precipated Florfenicol is removed by filtration
  3. stirringthen stirred for about another 1 hour
  4. customThe resulting precipitated Flunixin
  5. filtrationis collected by filtration
  6. customthen dried to a moisture content of less than about 1%

出典と根拠

ORDレコード
ord-aa034fbb34ea4023ae02c6dcb9a4a230
出典データセット
uspto-grants-2013_08
特許番号
US08501788B2

関連ノート

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