Ammonia → HCID 178441303、化合物

HRID 1888684

反応式

HRID 1888684 の反応式
[C:1]([N:5]1[CH:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[C:7](=[NH:14])[S:6]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([OH:28])(=O)[C:16]1([CH2:26][CH2:25][CH:21]([C:22](O)=[O:23])[C:18]1([CH3:20])[CH3:19])[CH3:17].[NH3:29]>CO>[CH2:10]([C:8]1=[CH:9][N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6]/[C:7]/1=[N:14]\[C:22]([C@H:21]1[CH2:25][CH2:26][C@@:16]([CH3:17])([C:15]([NH2:29])=[O:28])[C:18]1([CH3:20])[CH3:19])=[O:23])[CH2:11][CH2:12][CH3:13]

参加物

5

反応物 3

HCID 222AmmoniaHCID 214911,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acidHCID 668672282-tert-Butyl-4-butylisothiazol-5(2H)-imine

生成物 1

HCID 178441303HCID 178441303、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The product from Example 92B and the (+) camphoric acid (Aldrich) were processed using the method described in Example 170 except that the methanol used to trap the intermediate was saturated with ammonia solution instead of methanol to afford the title compound. 1H NMR (DMSO-d6) δ 0.50 (s, 3H), 0.90 (t, J=7.2 Hz, 3H), 1.19 (s, 3H), 1.23-1.44 (m, 3H), 1.26 (s, 3H), 1.57 (s, 9H), 1.57-1.71 (m, 3H), 1.93-2.06 (m, 1H), 2.71-2.82 (m, 1H), 2.62-2.69 (m, 3H), 7.01 (s, 1H), 6.75 (s, 1H), 8.50 (s, 1H). MS (ESI+) m/z 394 (M+H)+. Anal. calcd. for C11H35N3O2S: C, 64.08; H, 8.96; N, 10.68. Found: C, 64.26; H, 9.10; N, 10.65.

後処理

  1. customused to trap

出典と根拠

ORDレコード
ord-a7405d8924b6428ca7d618916c83d8e4
出典データセット
uspto-grants-2013_08
特許番号
US08501794B2

関連ノート

読み込み中…