Potassium Carbonate → 1-{5-[(4-Ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethanone

HRID 1888741

反応式

HRID 1888741 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](=[O:12])[CH3:11])=[CH:7][C:6]=2[CH:13]=1.[CH2:14]([O:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21]Cl)=[CH:19][CH:18]=1)[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cl-].[Na+].O>[CH2:14]([O:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][O:1][C:2]2[CH:3]=[CH:4][C:5]3[O:9][C:8]([C:10](=[O:12])[CH3:11])=[CH:7][C:6]=3[CH:13]=2)=[CH:19][CH:18]=1)[CH3:15]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 20639711-(Chloromethyl)-4-EthoxybenzeneHCID 32378771-(5-Hydroxy-1-benzofuran-2-yl)ethanone

生成物 1

HCID 670158661-{5-[(4-Ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethanone収率 163.5%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 57417360Sodium chloride; water溶媒

反応条件

温度
50 °C

実験手順

To a solution of 1-(5-hydroxy-1-benzofuran-2-yl)ethanone (2.40 g, 13.7 mmol) in anhydrous DMF (1 mL) were added 4-ethoxybenzyl chloride (2.81 g, 16.5 mmol) and potassium carbonate (3.78 g, 27.4 mmol) and the mixture was stirred at 50° C. overnight. Saturated brine was added thereto, and the mixture was extracted three times with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1-{5-[(4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethanone (6.95 g). This was directly used for the next reaction.

後処理

  1. extractionthe mixture was extracted three times with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-852283389d0e4a479baaeb76ed08dc28
出典データセット
uspto-grants-2013_08
特許番号
US08501804B2

関連ノート

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