Hydrazine → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 1889049

反応式

HRID 1889049 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]CC)=O)[S:5][CH:6]=1.[NH2:12][NH2:13]>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

生成物 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 4-methyl-1,3-thiazole-2-carboxylate (I120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg.

後処理

  1. temperaturethe solution was heated
  2. temperatureto reflux for 18 hours
  3. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-98724bebacf9490c9529b3bed35afff4
出典データセット
uspto-grants-2013_08
特許番号
US08501946B2

関連ノート

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